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心血管病研究所学术报告-Chen-Leng Cai

2016-1-18 9:23:39点击:
 

嘉宾:Chen-Leng Cai, Ph.D.

Associate Professor

Department of Developmental and Regenerative Biology

Icahn School of Medicine at Mount Sinai, New York

报告题目:Cardiac Progenitor Cells in Heart Development and Regeneration

时间:2016118日(周一)1430-1530

地点:心血管病研究所 学术报告厅

人民路708 苏州大学南校区1号楼41629

主办单位:苏州大学心血管病研究所

演讲嘉宾简介:

Cardiogenesis, the induction and subsequent development of the heart, is a critical event during embryogenesis. Mutations in genes expressed in the early heart cause defective cardiac development, and are responsible for embryonic lethality and congenital heart disease, occurring in ~1% of live births and 10% of stillbirths in humans. Dr. Cai’s laboratory uses mouse as a model system to study the molecular pathways controlling heart development and disease. Uncovering signaling cascades underlying early heart development also has great implications for the research of cardiac regenerative biology.

Dr. Cai’s previous research has showed that Isl1 (Islet1), a Lim-homeodomain transcription factor, labels a cardiac progenitor population that gives rise to the majority of cardiac segments (right ventricle, outflow tract and atria). In addition to the study of Isl1, Dr. Cai also discovered that T-box transcription factor Tbx20 plays critical roles in regulating cardiac cell proliferation and specification. More recently, Dr. Cai identified another cardiac progenitor population, Tbx18-expressing proepicardial and epicardial cells that can gives rise to both myocytes and non-myocytes cardiac lineages during early heart development. The Cai laboratory is currently performing research to decipher the transcriptional networks of Isl1 and Tbx20 in heart development. They are also interested in exploring the therapeutic potential of Isl1, Tbx18 and c-kit progenitor cells in cardiac repair and regeneration.

His work have been published in Nature, Nat Communications, Development Cell, and among others.

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