嘉宾：Y. Eugene Chen, MD, Ph.D / 陈育庆

Frederick Huetwell Professor of Cardiovascular Medicine，University of Michigan.

Director，Center for Advanced Models for Translational Sciences and Therapeutics

Vice Chair，Basic and Translational Research in the Department of Cardiac Surgery

报告题目：Creation of iPS cell-derived smooth muscle cells for modeling human aortic diseases

时间：2015年12月9日（周三）16：00-17：00

地点：心血管病研究所

人民路708号 苏州大学南校区1号楼4楼 学术报告厅

主办单位：苏州大学心血管病研究所

演讲嘉宾简介：

Dr. Chen’s research in vascular medicine is elucidating the molecular basis of obesity-and diabetes-induced cardiovascular diseases (CVD) and stroke, and on developing new drugs and technologies to study and treat diabetes and CVD.

Dr. Chen’s laboratory has made significant contributions to the understanding of the role of PPAR activation as a determinant of vascular cell gene expression and cellular function. His lab’s work was also among the first to define the role of PPAR activation in cardiovascular system. The discovery of high affinity physiological PPAR ligands, nitro-fatty acids advances our understanding of endogenous PPAR modulation and provides novel therapeutic strategies for treating obesity/diabetes and CVD. Dr. Chen was the first to clone the exendin4 (BYETTA, the drug name for Exendin4) gene. His work have been published in JCI, Biomaterial, and among others.

As the director of the Center for Advanced Models for Translational Sciences and Therapeutics, Dr. Chen is among the first in the world to produce gene knockout and knockin transgenic animals in non-rodent species using advanced technologies such as ZFN, TALEN, CRISPR/Cas9, and Somatic Cell Nuclear Transfer. And he also has the technology platform for Embryonic Stem Cells (ESC) and Induced

Pluripotent Stem Cells (iPSC).

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